Endocrine Abstracts

Thyroid nodules were frequently incidentally discovered during radiologic studies of chest or neck. We investigated the prevalence and clinical importance of thyroid incidentaloma during carotid artery ultrasonography in patients with diabetes. We retrospectively reviewed the data of enrolling all diabetic patients who were performed carotid artery ultrasonography at the Diabetes Center of Wonju Severance Christian Hospital from January to December 2013. Chart reviews of all e...

Pyruvate dehydrogenase kinase 4 (PDK4) activation is associated with metabolic diseases including hyperglycemia, insulin resistance, allergies, and cancer. We report here a new series of allosteric PDK4 inhibitor modified from hit anthraquinone. A novel PDK4 inhibitor, namely compound 8c, improved glucose tolerance in diet-induced obese mice. PDH activity in muscle and liver was enhance d by compound 8c treatment. Given the importance of PDK4 in immune cells including mast cel...